The objective of present study was to attempt to diagnose the risk factors of LHD with KOA cost effectively even at early prognostic stage by analyzing the abnormal internationally-acclaimed functional disabilities such as WOMAC, KOOS, ODI, and BMI anomalous serum levels of biochemical parameters such as IL-10,TNF-α, CRP, CK-MM, and AldoA, and deranged lower-anatomical features (KGB, DCM, DTM, SLR, KFS, and KES) in combination with abnormal radiological images as assessed by the Kellgren–Lawrance (KL) grading scale of the experimental cohorts compared with the healthy control subjects. The gene discussed is IL10; the disease is familial dilated cardiomyopathy.