Knockdown of HK2 by siRNA in spheroids formed from ascites-derived tumor cells (Figure 5D) inhibited lactate production (Figure 5E), cell migration, invasion, sphere-formation abilities (Figure 5F), FAK/ERK1/2 activation (Figure 5G), and metastasis- and CSC-related gene expression (Figure 5H). This evidence concerns the gene HK2 and neoplasm.