ZEB1 and cancer: It was shown that SNHG6 may epigenetically inactivate P27 through EZH2-dependent histone H3 methylation (H3K27me3) in the promoter of the P27. SNHG6 promotes the EMT by acting as a ceRNA, or a molecular sponge for miR-101-3p, thereby upregulating ZEB1 at the post-transcriptional level and enhancing cancer cell migration [64].