NF-κB can mediate activation of the cytokines/chemokines IL-1, IL-8, TNF, IL-6, and MCP-1; the pro- and anti-apoptotic factors cIAP, c-FLIP, A20, and BCL-XL; the vascular endothelial growth factor (VEGF); and matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9) in normal and cancer cells in response to various stimuli. This evidence concerns the gene VEGFA and cancer.