In the MLN, colitis also reduced the expression of Nrf2 (Nfe2l2), γ-glutamylcysteine synthetase (Gclc), glutathione reductase (Gsr), Gpx1, and Gpx2 by 27% to 45% relative to the non-colitic control (Figure 5B). Here, GCLC is linked to colitis.