The same work highlighted the isolation of exosomes from cell culture supernatants of colorectal cancer (CRC) cells, CRC interstitial fluid, and patients’ plasma-derived exosomes: CK19 was commonly expressed in exosomes derived from colorectal cells, TAG72 was mainly expressed in exosomes of 5-FU-resistant CRC cells, and CA125 in those of highly metastatic CRC cells. The gene discussed is KRT19; the disease is colorectal carcinoma.