To test this notion, we evaluated the transcriptional and translational levels of PBRM1 in tissues of patients with PCa and benign prostatic hyperplasia (BPH), and in four prostate lineages, including one non-neoplastic (RWPE-1), one androgen-responsive (LNCaP), and two CRPC cell lines (PC-3 and DU-145). This evidence concerns the gene PBRM1 and posterior cortical atrophy.