To test this notion, we evaluated the transcriptional and translational levels of PBRM1 in tissues of patients with PCa and benign prostatic hyperplasia (BPH), and in four prostate lineages, including one non-neoplastic (RWPE-1), one androgen-responsive (LNCaP), and two CRPC cell lines (PC-3 and DU-145). The gene discussed is PBRM1; the disease is benign prostatic hyperplasia.