CD28 and relapsing-remitting multiple sclerosis: We also demonstrated that CD28-induced c-myc expression depended on IL-6 that, as we have previously demonstrated [32], is strongly up-regulated in both HD and RRMS patients by CD28 (Figure S4c) and by activating STAT3 in both HD [32] and RRMS patients (Figure S4a) cooperated with RelA/NF-κB, as demonstrated by the strong inhibition of c-myc expression exerted by culturing T cells in the presence of anti-IL-6 Abs (Figure 4i) or S31-201 STAT3 inhibitor, (Figure 4l) or PS1145 NF-κB inhibitor (Figure 4m).