CD28 and Huntington disease: To this aim, CD4+ T cells from HD were stimulated with agonistic anti-CD28 (CD28.2) alone or in combination with anti-CD3 (UCHT1) or isotype control Abs and after 18 h aerobic glycolysis and oxidative phosphorylation were analyzed by measuring the extracellular acidification rate (ECAR) and oxygen-consumption rate (OCR), respectively.