Zaslaysky et al. also revealed that three major LPARs (LPAR1-3) form homo- or hetero-dimers within the LPAR subgroup and hetero-dimers with sphingosine 1 phosphate receptor (S1PR), pH-sensing G protein-coupled receptor (GPR4), and ovarian cancer G-protein coupled receptor-1 (OGR1/GPR68) [101], thereby activating the downstream signaling pathways linked to inflammation and fibrosis. The gene discussed is GPR68; the disease is ovarian cancer.