POU2F1 and cancer: To investigate regulatory pathways involved in the expression and activity of the transcription factors relevant in stress conditions, we analyzed the ability of the genotoxic drug Dox to modulate the expression and DNA binding activity of octamer-binding transcription factors in human cancer cell lines, given the role of Oct-1 as a stress sensor and regulator of cell survival in response to various types of stresses, including DNA damage [12,13].