CXCL8 and infection: SpyCEP is highly expressed in vivo [189] and cleaves CXC chemokines, including CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, and CXCL8 [187,188,190], which results in an impaired chemoattraction of eosinophils, neutrophils, and monocytes to the site of infection [189,191].