In contrast, variants in IDH2, TP53, ATRX, HRAS, and VHL were exclusively found by tumor sequencing, and variants in NF1 were more frequently found in tumor tissues (5/24 variants in 21 tumor cases) compared to germline testing (1/19 variants identified in our clinical cohort of 65 patients (Figure 2b). Here, VHL is linked to neoplasm.