Also in this study, we observed in the 4T1 breast carcinoma, CT26 colorectal carcinoma, and E.G7-OVA T-cell lymphoma model that expression of perforin in MDSCs isolated from the spleen was significantly lower, and in the E.G7-OVA T-cell lymphoma was even undetectable when compared to the MDSCs isolated from the respective tumors. The gene discussed is PRF1; the disease is T-cell non-Hodgkin lymphoma.