EDN1 and preeclampsia: Consistently, the imprinting control region (IG-DMR) of the DLK1-MEG3 cluster was very recently found hypermethylated in human umbilical veins from preeclamptic pregnancies, with an altered expression of both imprinted genes, a lower secretion of nitrite, VEGF and a higher secretion of endothelin 1 (ET1) all factors able to mediate pathological mechanisms in the offspring from preeclampsias [246].