PANK1 and Cognitive impairment: Interestingly, a group of disorders associated with the CoA biosynthetic pathway have the CNS as their primary target, for example, pantothenate kinase-associated neurodegeneration (PKAN), caused by pantothenate kinase 2 (PANK2) mutations, and HARP syndrome [25,58]; these are often characterised, like HD, by cognitive impairment, movement disorders, psychiatric features, and major brain-focussed neurodegeneration [59].