ESRRG and familial dilated cardiomyopathy: On the other hand, a key role of ERRγ in DCM has been recently suggested by in vitro studies showing that adenoviral-mediated ectopic overexpression of ERRγ in mouse cardiomyocytes is sufficient to recapitulate most of the alterations found in diabetic hearts, including increased Pdk4 expression, enhanced fatty acid oxidation, activation of the transcriptional program related to lipid metabolism, particularly lipid catabolism, and increased cardiomyocyte size [42].