Some features of CD11b deficiency like enhanced activation of NFκB and other TLR-dependent pathways [38], Th-17 cells expansion [1], higher activity of DCs and production of some pro-inflammatory cytokines, e.g. IL-1β, IL-6, IL-12, IL-23, and TNF-α [39], are observed in psoriasis. The gene discussed is ITGAM; the disease is psoriasis.