As a result of this approach we selected and investigated the following genetic variations: SNP rs2910164 in miR-146a and SNPs rs4597342 in 3'UTR of ITGAM as an associated target of miR-21, rs1368439 in 3'UTR of IL12B as an associated target of miR-513a-5p and rs1468488 in 3'UTR of IL17RA as an associated target of miR-320a in psoriasis. The gene discussed is IL17RA; the disease is psoriasis.