Although our LD analysis suggests that the rare variants of the three most common ITGAM SNPs, i.e. rs1143678, rs1143679 and rs1143683, are not within the same haplotype as the rs4597342 T allele, SLE and psoriasis do share some inflammatory features which might be associated with functionally deficient CD11b as a result of these SNPs. The gene discussed is ITGAM; the disease is systemic lupus erythematosus.