In accordance with our findings, a previous study has revealed that intestinal microbiota deficiency and decreased SCFAs’ productions are necessary for NLRP3 inflammasome activation and IL-1β production [44], suggesting that intestinal microbiota dysbiosis is critical for NLRP3 inflammasome activation. This evidence concerns the gene NLRP3 and hyperinsulinemic hypoglycemia, familial, 4.