Because the circadian clock greatly influences diurnally-regulated functions prominent in the retina [25,74], ascribing the myopia in rBmal1 KO mice to a clock disorder is consistent with the known role of diurnal rhythms in refractive development and to the alterations in rhythms of ocular dimensions and clock gene expression in experimental models of myopia as discussed in the Introduction [19,22–24]. This evidence concerns the gene CLOCK and myopia.