ADORA2A in the amygdala has a role in anxiety.36 RASD Family Member 2 (Rasd2), also down‐regulated in the PFC of fasting or E2 treated mice, is also affected by chronic stress in the PFC of mice.37 Complexin 3 (Cplx3) was induced in HP by both fasting and estrogen. The gene discussed is ADORA2A; the disease is Anxiety.