During IDD, proinflammatory cytokines, such as TNF‐α and IL‐1β could accelerate NP cells degeneration by promoting the release of matrix metalloproteinases (MMPs) and inflammatory cytokines.10, 11, 12, 13 It has been confirmed that ECM degradation and inflammation play a critical role in accelerating IDD progression. The gene discussed is IL1B; the disease is intervertebral disk degenerative disorder.