Our previous study has indicated the role of angiopoietin family proteins in IDD.22 One of the members in ANGPTL family, angiopoietin‐like proteins 8 (ANGPTL8), which is also known as lipasin or betatrophin, is a regulator of plasma lipid metabolism and a therapeutic target in diabetes mellitus.23, 24, 25, 26, 27 Nevertheless, the role of ANGPTL8 in inflammation and related signalling pathway is unknown. The gene discussed is ANGPTL8; the disease is diabetes mellitus.