NFKB1 and intervertebral disk degenerative disorder: The NF‐κB signalling pathway has been verified to play a role in promoting the apoptosis and senescence of NP cells, and increasing matrix‐degrading enzyme activity and mediating inflammatory response in IDD.16, 51 Thus, inhibiting the NF‐κB signalling pathway has a therapeutic potential in the progression of IDD.12, 14, 17, 51, 52 In the NF‐κB signalling pathway, activation of IKK complex results in the phosphorylation of IκBα and p65.