The NF‐κB signalling pathway has been verified to play a role in promoting the apoptosis and senescence of NP cells, and increasing matrix‐degrading enzyme activity and mediating inflammatory response in IDD.16, 51 Thus, inhibiting the NF‐κB signalling pathway has a therapeutic potential in the progression of IDD.12, 14, 17, 51, 52 In the NF‐κB signalling pathway, activation of IKK complex results in the phosphorylation of IκBα and p65. The gene discussed is NFKBIA; the disease is intervertebral disk degenerative disorder.