Our previous study has indicated the role of angiopoietin family proteins in IDD.22 One of the members in ANGPTL family, angiopoietin‐like proteins 8 (ANGPTL8), which is also known as lipasin or betatrophin, is a regulator of plasma lipid metabolism and a therapeutic target in diabetes mellitus.23, 24, 25, 26, 27 Nevertheless, the role of ANGPTL8 in inflammation and related signalling pathway is unknown. Here, ANGPTL8 is linked to intervertebral disk degenerative disorder.