Second, it was confirmed that chronic and not acute inflammation promotes the IDD progression, and an acute inflammation model in their study may have a tremendous difference with IDD model.59, 60 Our study revealed that ANGPTL8 participates in the regulation of ECM metabolism and inflammation partly through the NF‐κB signalling pathway; nevertheless, the more involved mechanisms are still unknown. This evidence concerns the gene NFKB1 and intervertebral disk degenerative disorder.