IL10 and Cowden disease: Because of the different roles of Th1/Th17 cells and Tregs in CD, the balance between pro‐inflammatory cells (Th1 and Th17) and anti‐inflammatory cells (Treg) can control immune‐mediated pathology and consequent tissue damage in CD.35, 36 Our results and previous research showed an imbalance between Tregs and Th1 and Th17 cells in IL‐10−/− mice, in which increased Th1 and Th17 responses and decreased Treg responses were observed compared to WT mice.