Inhibition of Gls1 by BPTES ([bis‐2‐(5‐phenylacetamido‐1,2,4‐thiadiazol‐2‐yl) ethyl sulfide], a Gls1 specific inhibitor19) could decrease Th17 and Th1 responses and increase the Treg response.19, 20, 21, 22, 23 These observations suggest an essential role of Gls1 in the generation of Th subsets (Th1, Th17 and Treg cells) in autoimmune diseases. Here, GLS is linked to autoimmune disease.