EIF2AK3 and cancer: ISR has been suggested as a protective process to hypoxia and nutrient deprivation, as it is up‐regulated in ischaemic regions of tumours.6, 7 ISR is also reported to be involved in tumour metastasis and EMT process8, 9 and required to adapt to high metabolic demand during oncogenic transformation.10 For example, EIF2AK3 activation has been shown to promote cell transformation in different tumour models.11, 12 However, whether ISR plays critical roles in therapeutic responses for cancer is still to be further investigated.