A recent study brought a hint that paclitaxel could induce degradation of glutamine carrier proteins and reduce glutamine uptake after long‐term administration of paclitaxel.43 Our study found that EIF2AK4 activated ISR within only 1 hour after paclitaxel treatment, which indicates that there may exist a more direct mechanism to achieve the level of ISR in the treated breast cancer cells. This evidence concerns the gene EIF2AK4 and breast carcinoma.