Notably, eNOS‐derived NO promotes Notch signalling, cell proliferation, EMT and differentiation during heart development, and has been implicated to play a role in ROS handling.35, 41, 42 In the present study, although there was no difference in the total eNOS protein levels between all four groups, levels of phosphorylated eNOS varied, being the lowest in OMD and highest in the two groups with maternal exercise. This evidence concerns the gene NOS3 and occult macular dystrophy.