Compared to INSR‐B, the INSR‐A has an increased mitogenic effect and binds both insulin‐like growth factor‐2 and INS with high affinity.19, 20 Previous study has shown that INS rs689 was associated with the risk of polycystic ovary syndrome,21 and there was a study indicated that INSR rs1799817 was related to the occurrence of type 2 diabetes (T2D). This evidence concerns the gene INS and type 2 diabetes mellitus.