INSR and metastatic malignant neoplasm in the lymph nodes: An association of INSR rs1799817 SNP with the risk of lymph node metastasis of patients with AEG was found in some subgroups (ever smoking subgroup: AA vs GG: adjusted P = .002; AA vs GG/GA: adjusted P = .001 and ever drinking subgroup: AA vs GG/GA: adjusted P = .030 [Table 9]).