TCF7L2 and cancer: It is observed that TCF7L2 rs290481 polymorphism was positively associated with cancer susceptibility under the additive model.27 The previous report showed that TCF7L2 rs290481 might influence the risik of HCC.14 Individuals carrying Crs290481Crs290487Ars290489 haplotype might have a significantly higher HCC susceptibility than those with Trs290481Trs290487Grs290489.