We identified that TCF7L2 rs290481, INS rs689 and INSR rs1799817 SNPs increased the susceptibility of AEG in different cancer stage subgroups (TCF7L2 rs290481; TC vs TT genetic model: adjusted P = .010; TC/CC vs TT genetic model: adjusted P = .008 for stage I/II subgroup; INS rs689; AA vs TT genetic model: adjusted P = .046; AA vs TT/TA genetic model: adjusted P = .045 for stage III/IV subgroup; INSR rs1799817; GA/AA vs GG genetic model: adjusted P = .034 for stage III/IV subgroup [Table 4]). The gene discussed is INS; the disease is cancer.