Previous studies have found that NRP–2 could act as a coreceptor that promote survival and migration in human endothelial cells.25 Besides, Muders et al proved that VEGF‐C/NRP–2/AKT‐1 axis is involved in protecting prostate cancer cells from H2O2‐induced oxidative stress.8 NRP–1 and NRP–2 are also expressed in human kidneys. This evidence concerns the gene VEGFC and prostate cancer.