Previous studies have found that NRP–2 could act as a coreceptor that promote survival and migration in human endothelial cells.25 Besides, Muders et al proved that VEGF‐C/NRP–2/AKT‐1 axis is involved in protecting prostate cancer cells from H2O2‐induced oxidative stress.8 NRP–1 and NRP–2 are also expressed in human kidneys. This evidence concerns the gene AKT1 and Familial prostate cancer.