The toxicity of mutant PD-associated proteins, including PINK1, Parkin, LRRK2, protein deglycase DJ-1,vacuolar protein sorting-associated protein 35, and α-synuclein, accounts for mitochondrial fission, impaired mitophagy, and neuronal death in the PD genetic models [15, 31]. Here, PRKN is linked to Parkinson disease.