So far, several studies have been carried out on the association of DRB1*1501 and MS in Iran.2,8-11 Also, there is a high spectrum of variation in Khuzestan Province, Iran, in neighborhood of the Arabic countries and the Persian Gulf due to high migration rate from different ethnic populations.12,13 As there is no study so far about HLA-DRB1*1501-DRB5*01 correlation with the mentioned disease and given the ethnic variation as well as based on the fact that Iranian Arabs are mostly located in Khuzestan Province, this survey might be of great importance. This evidence concerns the gene HLA-DRB1 and myeloid sarcoma.