SIRT1 and type 2 diabetes mellitus: Recently, we further determined that the reduced SIRT1 signaling pathway dramatically exacerbated myocardial ischemia/reperfusion injury both in type 1 and type 2 diabetic models, and stimulation of SIRT1 by honokiol or melatonin could significantly ameliorate the damage by preventing oxidative stress and apoptosis [24, 36].