SOD2 and familial dilated cardiomyopathy: As mitochondrial dysfunction caused by metabolic disorders is the main origin of ROS generation in DCM [10, 48], SOD2 has an extremely pivotal role in regulating ROS homeostasis after being deacetylated from Ac-SOD2 by the effect of several kinds of sirtuins, in which SIRT1 plays a crucial role [47, 49].