In fact, Parkin can positively regulate the expression of PDHA1 reducing, in this way, mitochondrial oxidative phosphorylation and increasing the glycolytic pathway [74, 76].1Because the Warburg effect represents a hallmark of cancer cells that, using aerobic glycolysis, try to sustain the energetic demand, it is clear that mitophagy and cancer can be strongly related. The gene discussed is PDHA1; the disease is cancer.