It is an arduous task to predict the role that mitophagy has on cancer cells because it depends on different factors like cancer type, cancer stage, genetic background [95], and equilibrium between cellular demand and availability; according to the scenario, mitophagic alterations can have a dual role acting as cancer suppressors like during Atg5 or Atg7 depletion or promoters like BNIP3, FUNDC1, and PINK1 deficiency. Here, ATG5 is linked to cancer.