WFDC2 and cancer: In order to further substantiate whether HE4 and ANXA2 interaction is ubiquitous in malignant tumor cells, we detected the expression and interaction of HE4 and ANXA2 in different malignant tumor cell lines, and then compared the differences between the proliferation, invasion, migration and adhesion of cell lines with different expressions level of HE4 and ANXA2.