The results showed interaction between HE4/ANXA2 and MMP2 was common in various malignant tumor cells including CaoV3, ES-2, OVCAR-3, Ishikawa, A549, HGC-27, SW480, HepG2, Hela, HT29 and HEK293 cell lines (Fig. 5a). This evidence concerns the gene ANXA2 and cancer.