CALCA and medullary thyroid gland carcinoma: Only one malignantnodule (the one diagnosed as medullary thyroid carcinoma) was classified as E1.In that particular case, the patient had a high level of calcitonin, as well asanother thyroid nodule, which was classified as Bethesda V. Of the five thyroidnodules characterized as benign by histology, three were classified as E1.