PLOD1 and polycystic ovary syndrome: PCOS up-regulates serum gonadotropin levels andsignificantly diminishes the estrogen and progesteronesynthesis versus control animals and/or fertile women (4).In corroboration with those reports, the animals in PCOS-sole groups showed higher serum LH and FSH levels, inaddition to lower levels of estrogen and progesterone versusthe control group.