In the pre‐apoptotic stage, immunogenic dead cells translocate calreticulin (CRT, a 46 kDa Ca2+‐binding protein), from the perinuclear ER to the cellular periphery and similarly relocalize ERp57.22 Once the CRT/ERp57 complex is exposed on the cell surface, it provides an ‘eat me’ signal to promote phagocytosis by DCs.15, 23 Moreover, the exposure of CRT on the surface of cancer cells succumbing to ICD also induces tumour antigen presentation and tumour‐specific CTL responses.15 The gene discussed is PDIA3; the disease is cancer.