In addition, the OS was significantly longer in the IDH1 wild‐type proneural patients (17.1 vs 12.8 months; HR: 0.43; 95% CI: 0.26‐0.73; P = 0.002; n = 103) (Table 1), which is consistent with the results of a previous study showing that proneural tumour cells were highly sensitive to blockage of the pathways downstream of VEGF.24 No significant difference in OS was observed in the mesenchymal subtype, although mesenchymal GBMs exhibit higher VEGF/angiogenic marker expression.25 Here, IDH1 is linked to neoplasm.