Ectopic expression of FOXD2‐AS1 reversed sorafenib resistance in HCC cells, whereas silencing of TMEM9 or overexpressing mir‐150‐5p partially restored this effect, indicating that FOXD2‐AS1 regulates sorafenib resistance via miR‐150‐5p/TMEM9 axis. Here, TMEM9 is linked to hepatocellular carcinoma.