In our study, the statistically significant difference in the levels of IL-2 was detected in the later stages of the experiment (8 weeks post-operatively), which could be explained by the anti-inflammatory role of the intra-articular administration of Fetuin-A, on the grounds that it enhanced the further decrease in the amounts of IL-2, as CD4 Th cells are mentioned to lower their levels on the later stages of the onset of arthritis. The gene discussed is CD4; the disease is Arthritis.