AKT1 and cancer: Moreover, our experiments show that plantaricin P1053 is able to reduce E705 cancer cells viability, although the mechanism involved is still not elucidated; at the same time its effect on healthy intestinal cells is an increase in viability, due to a transient phosphorylation of both Akt and Erk which is achieved with a different timing and is readily switched off in 24 h.