Data from the literature have documented that patients with +12, +18 and +19 although resembling a CK are characterised by an indolent CLL with peculiar clinical features (i.e. female predominance, young age at diagnosis, etc.);27 on the other hand the presence of at least five chromosomal aberrations predicted for a very aggressive clinical course independently of the IGHV status and TP53 lesions.29 The number of chromosomal lesions was also assessed in our study population, confirming that patients 5 or more aberrations had the shortest TTFT and OS (Fig. S5). This evidence concerns the gene TP53 and B-cell chronic lymphocytic leukemia.