Consistent with these observations, we found Tnfα, IL17, and Ifnγ mRNA were significantly increased in small intestines of SCD mice; and claudin 3 and claudin 15 mRNA were significantly decreased in SCD mice compared with Ctrl, suggesting increased intestinal permeability; these gene expression changes were partially rescued with Abx treatment. Here, CLDN3 is linked to Schnyder corneal dystrophy.