Various studies have illustrated that the application of exogenous HMGB1 before the release of endogenous HMGB1 immediately after MI can improve harmful outcomes of structure and function after MI through cardiac repair7, angiogenesis8,38, prevention of apoptosis and induction of autophagy to promote myocardial cell survival39, and improvement of cardiac function40. The gene discussed is HMGB1; the disease is myocardial infarction.