In order to identify unique characteristics of FL, we compared our FL dataset with the results reported for CD5-/IgM+normal B cells and other B-cell lymphoproliferative disorders (B-LPDs), namely, de novo DLBCL, MCL, CLL, SMZL, hairy cell leukemia (HCL), multiple myeloma (MM) and WM (Table 2 and Supplemental Table S6)19,21,39–44. This evidence concerns the gene CD5 and splenic marginal zone lymphoma.