RIPK3 and MLKL, which are key regulators of necroptosis, were upregulated in both murine NASH models and NASH patients20, and necroptosis inhibition in Ripk3 KO mice shows decreased serum AST and ALT, inflammatory cytokines, and fibrosis5. This evidence concerns the gene RIPK3 and metabolic dysfunction-associated steatohepatitis.