We have no direct information concerning the mechanisms by which transgenic IMP2 overexpression causes hepatic steatosis; however, a plausible inference is that transgenic overexpression of IMP2 in hepatocytes modifies the abundance of client RNAs, including IGF2 mRNA (13) and perhaps including some mRNAs not recruited by the normally low levels of IMP2 in adult hepatocytes. This evidence concerns the gene IGF2BP2 and Hepatic steatosis.