Numbers of lung metastatic nodules were dramatically lower in 4 T1-bearing mice treated with ttIL-12 + S than in those treated with control plasmid plus surgery (Ctrl+S), while wtIL-12 + S slightly decreased lung metastatic nodules in both 4 T1 and LM8 tumor–bearing mice (Fig. 3a, c). The gene discussed is CTRL; the disease is neoplasm.