By analyzing The Cancer Genome Atlas (TCGA) data across different human tumors for markers of immunostimulatory interferon-gamma (IFNγ)–positive CD8+ cytotoxic T cells and immunosuppressive Tregs and MDSCs, we found that the immune profile IFNγHiCD8aHiFOXP3LowCD33Low predicted excellent patient outcome across different tumor types. The gene discussed is IFNG; the disease is cancer.