Moreover, measurement of levels of CXCL9 and CXCL10 proteins, which are CD8+ T cell attractants, showed that ttIL-12 increased CXCL9 levels in both primary tumor and lung metastatic nodules in the 4 T1 and LM8 models, while ttIL-12 increased CXCL10 levels only in lung metastatic tumors in the 4 T1 model and liver metastatic tumors in the LM8 model (Fig. 5a, Additional file 1: Figure S6C). The gene discussed is CXCL9; the disease is neoplasm.