SLC5A2 and type 2 diabetes mellitus: CVD-REAL was a RWE study that compared the rate of HHF in individuals with T2D who had been newly initiated on SGLT2 inhibitors (canagliflozin, dapagliflozin or empagliflozin) versus other glucose-lowering drugs (oGLDs), with secondary aims of comparing the risk of all-cause death, and HHF or all-cause death, between the two treatment groups [29].