SLC5A2 and type 2 diabetes mellitus: Until recently, three SGLT2 inhibitors had been approved by the EMA and FDA for the treatment of T2D, as an adjunct to diet and exercise: canagliflozin (approval: EMA/FDA 2013); dapagliflozin (approval: EMA 2012/FDA 2014); and empagliflozin (approval: EMA/FDA 2014).