A/CPA, aldosterone- and cortisol-producing adenoma; APA, aldosterone-producing adenoma; ARR, aldosterone-to-renin ratio; AVS, adrenal venous sampling; BPA, Bilateral partial adrenalectomy; CPA, cortisol-producing adenoma; CS, Cushing’s syndrome; HE, hematoxylin–eosin stain; IHC, Immunohistochemical; LPA, Left partial adrenalectomy; LTA, Left total adrenalectomy; NM, not mentioned; PAC, plasma aldosterone concentration; PRA, plasma renin activity; RPA, Right partial adrenalectomy; RTA, Right total adrenalectomy. This evidence concerns the gene REN and Cowden syndrome 1.