PRKN and Parkinson disease: About 10% of PD cases are inherited forms of disease, and many PD-associated genes have been identified, including SNCA(PARK1/4), Parkin(PARK2), LRRK2(PARK8), PINK1(PARK6), UCHL-1(PARK5), DJ-1(PARK7), ATXN2, ATXN3, PLA2G6, ATP13A2(PARK9) and so on [5, 6].