Transgenic NSCLC mice in which expression of Nanos3 was induced (Nanos3LSL/−;LSL-KRasG12D;p53fl/fl;CCSP-rtTA+/−;TetO-Cre+/−) are hereafter referred to as Nanos3 NSCLC mice. The gene discussed is NANOS3; the disease is non-small cell lung carcinoma.