Since ubiquitous expression of Nanos3 turned out to be embryonically lethal, the correct localization of Nanos3 protein expression seems to be important in the mammalian embryo, as seen in Drosophila. By using the Nanos3LSL mouse model, it will be possible to further investigate the in vivo role of ectopic Nanos3 expression in NSCLC and other cancer types. Here, NANOS3 is linked to cancer.