Based on a large-scale study including 2316 NSCLC patient, our study demonstrated the EGFRex20ins distribution in EGFR mutant Chinese patients (4.8%), the most common EGFRex20ins mutation (A767_V769dup) and co-mutation (TP53), as well as clinical characteristics of EGFRex20ins in Chinese NSCLC patients. This evidence concerns the gene EGFR and non-small cell lung carcinoma.