Further, the gene L-2-hydroxyglutarate dehydrogenase (L2HGDH) (spearman = − 0.252, p < 0.005) has been identified in the MSC, showing that the expression level of this gene may be an indication of treatment outcome for these eight RTK inhibitors in CNS-cancer cell lines. The gene discussed is L2HGDH; the disease is central nervous system cancer.